Let's solve the expression step by step:

### Expression:
\[
4(-7776) - 216(36)
\]

#### Step 1: Multiply 4 by -7776
\[
4 \times (-7776) = -31104
\]

#### Step 2: Multiply 216 by 36
\[
216 \times 36 = 7776
\]

#### Step 3: Subtract the results
\[
-31104 - 7776 = -38880
\]

### Final Answer:
\[
-38880
\]

Would you like a detailed explanation of any of the steps?

Here are 5 related questions to expand on this topic:
1. How does the distributive property work in larger expressions?
2. What is the best method to simplify expressions with multiple operations?
3. How do you handle negative signs in multiplication and subtraction?
4. Can you explain the difference between distributing and factoring in algebra?
5. How can we verify if a solution to an algebraic expression is correct?

**Tip:** Always perform multiplication and division before addition and subtraction to follow the order of operations (PEMDAS).

Learn how to solve the expression 4(-7776) - 216(36) using multiplication and subtraction. This problem focuses on applying the order of operations and handling negative numbers. Suitable for students in Grades 6-8.

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