Math Problem Statement

A country is screening for a specific disease in its population. The diagnostic test has the following characteristics:

The sensitivity (probability of testing positive if infected) is 95%.

The specificity (probability of testing negative if not infected) is 98%.

The prevalence of the disease in the population is 0.5%.

Tasks:

1.     Conditional Probability Analysis: a) What is the probability that a person tests positive given that they are actually infected? b) What is the probability that a person who tests negative is actually healthy? c) What is the probability that a person who tests positive is actually infected? (This is a key aspect of positive predictive value.)

Solution

Let's break this down step by step using the definitions and the given information:

Definitions and Given Information:

  • Sensitivity: The probability of testing positive if the person is actually infected. Here, it's given as 95% (0.95).
  • Specificity: The probability of testing negative if the person is not infected. Here, it's given as 98% (0.98).
  • Prevalence: The proportion of the population that is actually infected. Here, it's given as 0.5% (0.005).

We are working with conditional probability and applying Bayes' Theorem for the positive predictive value.

1. Conditional Probability Analysis

a) What is the probability that a person tests positive given that they are actually infected?

This is directly the sensitivity of the test, as it gives the probability that an infected person tests positive.

P(Positive testInfected)=Sensitivity=0.95P(\text{Positive test} | \text{Infected}) = \text{Sensitivity} = 0.95

So, the probability that a person tests positive given that they are infected is 95%.


b) What is the probability that a person who tests negative is actually healthy?

This refers to the negative predictive value, i.e., the probability that a person who tests negative is not infected. This can be calculated using the formula:

P(HealthyNegative test)=P(Negative testHealthy)P(Healthy)P(Negative test)P(\text{Healthy} | \text{Negative test}) = \frac{P(\text{Negative test} | \text{Healthy}) \cdot P(\text{Healthy})}{P(\text{Negative test})}

First, let's calculate the needed components:

  • Specificity is the probability of a negative test when healthy, so: P(Negative testHealthy)=0.98P(\text{Negative test} | \text{Healthy}) = 0.98

  • Prevalence (the proportion of infected people in the population) is: P(Healthy)=1Prevalence=10.005=0.995P(\text{Healthy}) = 1 - \text{Prevalence} = 1 - 0.005 = 0.995

Now, we need to calculate the total probability of testing negative (P(Negative test)P(\text{Negative test})):

P(Negative test)=P(Negative testHealthy)P(Healthy)+P(Negative testInfected)P(Infected)P(\text{Negative test}) = P(\text{Negative test} | \text{Healthy}) \cdot P(\text{Healthy}) + P(\text{Negative test} | \text{Infected}) \cdot P(\text{Infected})

Where:

  • P(Negative testInfected)=1Sensitivity=10.95=0.05P(\text{Negative test} | \text{Infected}) = 1 - \text{Sensitivity} = 1 - 0.95 = 0.05
  • P(Infected)=Prevalence=0.005P(\text{Infected}) = \text{Prevalence} = 0.005

Now we compute P(Negative test)P(\text{Negative test}):

P(Negative test)=(0.980.995)+(0.050.005)=0.9751+0.00025=0.97535P(\text{Negative test}) = (0.98 \cdot 0.995) + (0.05 \cdot 0.005) = 0.9751 + 0.00025 = 0.97535

Finally, we calculate the probability that a person who tests negative is actually healthy:

P(HealthyNegative test)=(0.980.995)0.97535=0.97510.975350.9997P(\text{Healthy} | \text{Negative test}) = \frac{(0.98 \cdot 0.995)}{0.97535} = \frac{0.9751}{0.97535} \approx 0.9997

So, the probability that a person who tests negative is actually healthy is approximately 99.97%.


c) What is the probability that a person who tests positive is actually infected?

This is the positive predictive value, and we can calculate it using Bayes' Theorem:

P(InfectedPositive test)=P(Positive testInfected)P(Infected)P(Positive test)P(\text{Infected} | \text{Positive test}) = \frac{P(\text{Positive test} | \text{Infected}) \cdot P(\text{Infected})}{P(\text{Positive test})}

Where:

  • P(Positive testInfected)=Sensitivity=0.95P(\text{Positive test} | \text{Infected}) = \text{Sensitivity} = 0.95
  • (P(\text{Infected}) = \text

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Math Problem Analysis

Mathematical Concepts

Conditional Probability
Bayes' Theorem
Sensitivity
Specificity
Positive Predictive Value
Negative Predictive Value

Formulas

P(Positive test | Infected) = Sensitivity
P(Healthy | Negative test) = (P(Negative test | Healthy) * P(Healthy)) / P(Negative test)
P(Infected | Positive test) = (P(Positive test | Infected) * P(Infected)) / P(Positive test)

Theorems

Bayes' Theorem

Suitable Grade Level

Grades 11-12