Math Problem Statement
A country is screening for a specific disease in its population. The diagnostic test has the following characteristics:
The sensitivity (probability of testing positive if infected) is 95%.
The specificity (probability of testing negative if not infected) is 98%.
The prevalence of the disease in the population is 0.5%.
Tasks:
1. Conditional Probability Analysis: a) What is the probability that a person tests positive given that they are actually infected? b) What is the probability that a person who tests negative is actually healthy? c) What is the probability that a person who tests positive is actually infected? (This is a key aspect of positive predictive value.)
Solution
Let's break this down step by step using the definitions and the given information:
Definitions and Given Information:
- Sensitivity: The probability of testing positive if the person is actually infected. Here, it's given as 95% (0.95).
- Specificity: The probability of testing negative if the person is not infected. Here, it's given as 98% (0.98).
- Prevalence: The proportion of the population that is actually infected. Here, it's given as 0.5% (0.005).
We are working with conditional probability and applying Bayes' Theorem for the positive predictive value.
1. Conditional Probability Analysis
a) What is the probability that a person tests positive given that they are actually infected?
This is directly the sensitivity of the test, as it gives the probability that an infected person tests positive.
So, the probability that a person tests positive given that they are infected is 95%.
b) What is the probability that a person who tests negative is actually healthy?
This refers to the negative predictive value, i.e., the probability that a person who tests negative is not infected. This can be calculated using the formula:
First, let's calculate the needed components:
-
Specificity is the probability of a negative test when healthy, so:
-
Prevalence (the proportion of infected people in the population) is:
Now, we need to calculate the total probability of testing negative ():
Where:
Now we compute :
Finally, we calculate the probability that a person who tests negative is actually healthy:
So, the probability that a person who tests negative is actually healthy is approximately 99.97%.
c) What is the probability that a person who tests positive is actually infected?
This is the positive predictive value, and we can calculate it using Bayes' Theorem:
Where:
- (P(\text{Infected}) = \text
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Math Problem Analysis
Mathematical Concepts
Conditional Probability
Bayes' Theorem
Sensitivity
Specificity
Positive Predictive Value
Negative Predictive Value
Formulas
P(Positive test | Infected) = Sensitivity
P(Healthy | Negative test) = (P(Negative test | Healthy) * P(Healthy)) / P(Negative test)
P(Infected | Positive test) = (P(Positive test | Infected) * P(Infected)) / P(Positive test)
Theorems
Bayes' Theorem
Suitable Grade Level
Grades 11-12
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