The expression $\sqrt{80}$ can be simplified by breaking down 80 into its prime factors.

1. Start by finding the prime factorization of 80: $80 = 2 \times 40 = 2 \times 2 \times 20 = 2 \times 2 \times 2 \times 10 = 2 \times 2 \times 2 \times 2 \times 5 = 2^4 \times 5$

2. Then, apply the square root to the prime factorization: $\sqrt{80} = \sqrt{2^4 \times 5}$

3. Since $\sqrt{2^4} = 2^2 = 4$, you can simplify the square root: $\sqrt{80} = 4\sqrt{5}$

So, the simplified form of $\sqrt{80}$ is $4\sqrt{5}$.

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Here are some related questions you might find useful:

1. How would you simplify $\sqrt{200}$?
2. What is the square root of $72$ simplified?
3. How do you express $\sqrt{45}$ in its simplest form?
4. Can you simplify $\sqrt{50}$?
5. What is the square root of $18$ simplified?

Tip: When simplifying square roots, look for perfect square factors.