The expression $-6 \times -3 + 4$ can be solved by following the order of operations (PEMDAS: Parentheses, Exponents, Multiplication and Division (from left to right), and Addition and Subtraction (from left to right)).

First, we handle the multiplication:

$-6 \times -3 = 18$

Now, we add 4 to the result:

$18 + 4 = 22$

Thus, the solution is:

$22$

Would you like more details or have any questions?

Here are five related questions to expand on this:

1. What is the result of $-7 \times -2 + 5$?
2. How would the result change if the multiplication were positive, e.g., $6 \times 3 + 4$?
3. What is the result of $-6 \times 3 + 4$?
4. How would you handle a similar expression like $-6 \times -3 + (-4)$?
5. Can you solve $-8 \times -5 + 12$?

Tip: Always perform multiplication before addition when solving expressions with both operations.