To solve the expression:

\[
250 + (-20) + 65 + (-46)
\]

1. Add \(250\) and \(-20\):
   \[
   250 - 20 = 230
   \]

2. Add \(230\) and \(65\):
   \[
   230 + 65 = 295
   \]

3. Add \(295\) and \(-46\):
   \[
   295 - 46 = 249
   \]

So, the final result is:

\[
249
\]

Would you like more details or have any questions?

Here are 5 related questions to expand your understanding:
1. How do you simplify expressions with multiple negative numbers?
2. What is the rule for adding negative and positive integers?
3. How would the result change if you added a positive number instead of a negative one?
4. Can you write an equation that results in a negative sum from this type of operation?
5. How can you use number lines to visualize operations involving negatives?

**Tip:** When adding and subtracting negative numbers, think of it as moving left or right on a number line.

Learn how to add and subtract integers with both positive and negative numbers. This example solves the expression 250 + (-20) + 65 + (-46), illustrating the key steps and concepts. Suitable for students in Grades 6-7, covering integer operations and properties of addition and subtraction.

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