The expression $(65) + (-21)$ can be solved by adding the two numbers together.

$65 + (-21) = 65 - 21 = 44$

So, the result is $44$.

Would you like more details or have any questions about this?

Here are 5 related questions:

1. What is the sum of $-35 + 12$?
2. How do you add integers with different signs?
3. What is the result of $100 + (-57)$?
4. Can you calculate $23 + (-45) + 10$?
5. What is the difference between adding positive and negative numbers?

Tip: When adding a negative number, you are essentially subtracting the absolute value of that number from the other number.