You can use the numbers 4, 2, 4, and 1 to equal 24 with the following expression:

$(4 \times 4) + (2 \times 1) = 16 + 8 = 24$

Here’s the step-by-step breakdown:

1. Multiply 4 by 4 to get 16.
2. Multiply 2 by 4 to get 8.
3. Add the results from step 1 and step 2: 16 + 8 = 24.

Would you like more details or have any questions? Here are some questions you might be interested in:

1. How do you solve equations with multiple steps?
2. Can you explain how to use the order of operations?
3. What are some other examples of using given numbers to reach a target number?
4. How can you use parentheses to change the outcome of expressions?
5. How do you simplify complex mathematical expressions?

Tip: Always remember to follow the order of operations (PEMDAS/BODMAS) when solving mathematical expressions to ensure accuracy.