Let's solve the expression:

The given expression is:

$2^2 \times 16$

First, calculate $2^2$:

$2^2 = 4$

Next, multiply by 16:

$4 \times 16 = 64$

Therefore, the answer is:

$\boxed{64}$

Would you like more details or have any questions?

Here are 5 related questions for further practice:

1. What is $3^2 \times 9$?
2. Calculate $5^3 \times 4$.
3. Simplify $2^3 \times 8$.
4. Evaluate $4^2 \times 6$.
5. Find the result of $2^4 \times 10$.

Tip: Remember that exponentiation is performed before multiplication according to the order of operations (PEMDAS/BODMAS).