The expression you provided is:

$5 \times 8 + (-3) \times 5$

Let's solve this step by step:

1. First, calculate $5 \times 8$: $5 \times 8 = 40$

2. Next, calculate $(-3) \times 5$: $(-3) \times 5 = -15$

3. Now, add the two results together: $40 + (-15) = 40 - 15 = 25$

Thus, the final result is:

$25$

Would you like further details or have any questions?

Here are 5 related questions for practice:

1. What is $6 \times 9 + (-4) \times 7$?
2. Calculate $8 \times 7 + (-2) \times 9$.
3. Simplify $5 \times (-3) + 6 \times 4$.
4. What is the result of $4 \times (-5) + 3 \times 6$?
5. Solve for $7 \times 5 + (-8) \times 4$.

Tip: When dealing with negative numbers in multiplication, remember that multiplying two numbers with opposite signs results in a negative number.