Rx Dextrose, anhydrous 2.5% (E-value = 0.18)

Sodium Chloride q.s.

Sterile Water for Injection ad 1000 mL

Label: Isotonic Dextrose and Saline Solution.

How many grams of sodium chloride should be used in preparing the solution? Your final answer should be numerical only. Round to one decimal place.

To determine how many grams of sodium chloride (NaCl) should be used, we can follow these steps:

1. **Dextrose's E-value is given as 0.18**, which means that 1 gram of dextrose has the same osmotic effect as 0.18 grams of NaCl.

2. **Total grams of dextrose** in the solution:
   \[
   2.5\% \text{ of } 1000 \text{ mL} = \frac{2.5}{100} \times 1000 = 25 \text{ grams of dextrose}
   \]

3. **Sodium chloride equivalent of dextrose** (based on E-value):
   \[
   25 \text{ grams of dextrose} \times 0.18 = 4.5 \text{ grams of NaCl}
   \]

4. **Amount of sodium chloride required to make an isotonic solution (0.9% NaCl solution)**:
   \[
   0.9\% \text{ of } 1000 \text{ mL} = 0.009 \times 1000 = 9 \text{ grams of NaCl}
   \]

5. **Actual sodium chloride needed** after accounting for the contribution from dextrose:
   \[
   9 \text{ grams} - 4.5 \text{ grams} = 4.5 \text{ grams}
   \]

The amount of sodium chloride needed is **4.5 grams**.

Would you like more details on this? 

Here are 5 related questions you might find interesting:
1. How is the E-value of a substance calculated?
2. What is the role of dextrose in isotonic solutions?
3. Why is 0.9% NaCl considered isotonic with body fluids?
4. What happens if too much NaCl is added to the solution?
5. Can the E-value vary between different substances?

**Tip:** When solving isotonicity problems, always account for the contribution of other solutes to the osmotic pressure!

Rx Dextrose, anhydrous 2.5% (E-value = 0.18)
Sodium Chloride q.s.
Sterile Water for Injection ad 1000 mL
Label: Isotonic Dextrose and Saline Solution.
How many grams of sodium chloride should be used in preparing the solution? Your final answer should be numerical only. Round to one decimal place.

Learn how to calculate the grams of sodium chloride required to prepare an isotonic solution with 2.5% anhydrous dextrose. This problem involves pharmaceutical math concepts, including E-values and osmotic pressure adjustments. Suitable for pharmacy or chemistry students.

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