To determine the missing number in this sequence, I need a bit more context regarding the specific method you're referring to. However, based on common methods for finding missing numbers in sequences (such as arithmetic or geometric progressions, patterns across rows or columns, or using a specific formula), I can help you approach the problem.

Some questions to clarify:

1. Are we looking for a specific mathematical method, like summation or differences between rows or columns?
2. Does the missing number depend on the surrounding numbers in the matrix?
3. Is there a known pattern that should be applied here (e.g., summing rows, taking averages, etc.)?
4. Should we consider the numbers above, below, or beside the missing value for the calculation?
5. Are the rows or columns related in any specific mathematical way?

Once I know the exact method you want to apply, I can walk you through solving for the missing number.

Potential Tip:

One common method is summing elements or calculating differences within rows, columns, or diagonals to reveal a pattern. This can help you spot consistent numerical relationships.

Let me know if you'd like help with this or more details!