It seems you want to evaluate a definite integral using the method of integration by substitution, but the integral expression isn't clear. Could you please provide the integral expression again?

For example, if you meant to write something like:

$\int_{0}^{\ln 2} e^{x} \sqrt{e^{x} + 4} \, dx$

Or:

$\int_{0}^{1} x \sqrt{1 + x^2} \, dx$

Please provide the full expression so I can help you solve it.