The equation for the statement "Twice the difference of a number and 6 equals 5" is:

$2(x - 6) = 5$

Here, $x$ represents the unknown number.

Would you like further explanation on solving this equation or any other details?

Here are five related questions:

1. How do you solve the equation $2(x - 6) = 5$?
2. What happens if the equation equals a different number, say 7?
3. How can we check the solution to the equation?
4. What if instead of 6, the number in the difference was 8?
5. How would the equation change if it said "three times the difference"?

Tip: Always simplify the equation step by step to avoid mistakes.