Math Problem Statement

The rate of change in the concentration C(t) of a drug with respect to time t is given by: dC/dt = -kC + D(t), where D(t) is the dosage at time t, and k is the rate at which the drug leaves the bloodstream. Solve the linear equation to show that if C(0) = 0, then C(t) = e^{-kt} ∫_0^t e^{ky} D(y) dy. Additionally, show that if D(t) is constant D(t) = D_0, then C(t) = (D_0 (1 - e^{-kt})) / k.

Solution

Let us solve the given problem step-by-step:


Problem:

The rate of change in the concentration C(t)C(t) of a drug with respect to time tt is given by:

dCdt=kC+D(t),\frac{dC}{dt} = -kC + D(t),

where D(t)D(t) is the dosage at time tt, and kk is the rate at which the drug leaves the bloodstream.

Part (a): Solve the linear equation to show that if C(0)=0C(0) = 0, then:

C(t)=ekt0tekyD(y)dy.C(t) = e^{-kt} \int_0^t e^{ky} D(y) \, dy.

Solution:

This is a first-order linear differential equation. The general method for solving such equations involves finding an integrating factor.

  1. Rewrite the equation: dCdt+kC=D(t).\frac{dC}{dt} + kC = D(t).

  2. Find the integrating factor: The integrating factor is: μ(t)=ekdt=ekt.\mu(t) = e^{\int k \, dt} = e^{kt}.

  3. Multiply through by the integrating factor: ektdCdt+kektC=ektD(t).e^{kt} \frac{dC}{dt} + k e^{kt} C = e^{kt} D(t).

    The left-hand side is the derivative of ektCe^{kt} C: ddt(ektC)=ektD(t).\frac{d}{dt} \left( e^{kt} C \right) = e^{kt} D(t).

  4. Integrate both sides: ektC=ektD(t)dt.e^{kt} C = \int e^{kt} D(t) \, dt.

  5. Solve for C(t)C(t): Divide through by ekte^{kt}: C(t)=ektektD(t)dt.C(t) = e^{-kt} \int e^{kt} D(t) \, dt.

    If C(0)=0C(0) = 0, the integral's lower limit is 00, so: C(t)=ekt0tekyD(y)dy.C(t) = e^{-kt} \int_0^t e^{ky} D(y) \, dy.

Thus, we have proved the desired result.


Part (b): Show that if D(t)D(t) is constant D(t)=D0D(t) = D_0, then:

C(t)=D0(1ekt)k.C(t) = \frac{D_0 (1 - e^{-kt})}{k}.

Solution:

  1. Substitute D(t)=D0D(t) = D_0 into the integral: Using the result from part (a): C(t)=ekt0tekyD0dy.C(t) = e^{-kt} \int_0^t e^{ky} D_0 \, dy.

    Since D0D_0 is a constant, it can be factored out of the integral: C(t)=ektD00tekydy.C(t) = e^{-kt} D_0 \int_0^t e^{ky} \, dy.

  2. Solve the integral: The integral of ekye^{ky} is: ekydy=1keky.\int e^{ky} \, dy = \frac{1}{k} e^{ky}.

    Evaluating from 00 to tt: 0tekydy=1k(ektek0)=1k(ekt1).\int_0^t e^{ky} \, dy = \frac{1}{k} \left( e^{kt} - e^{k \cdot 0} \right) = \frac{1}{k} \left( e^{kt} - 1 \right).

  3. Substitute back: C(t)=ektD01k(ekt1).C(t) = e^{-kt} D_0 \cdot \frac{1}{k} \left( e^{kt} - 1 \right).

  4. Simplify: Multiply through: C(t)=D0k(1ekt).C(t) = \frac{D_0}{k} \left( 1 - e^{-kt} \right).

Thus, we have proved the desired result.


Summary of Results:

  1. If C(0)=0C(0) = 0, then: C(t)=ekt0tekyD(y)dy.C(t) = e^{-kt} \int_0^t e^{ky} D(y) \, dy.

  2. If D(t)=D0D(t) = D_0, then: C(t)=D0k(1ekt).C(t) = \frac{D_0}{k} \left( 1 - e^{-kt} \right).


Would you like further clarification on any steps? Here are five questions for practice or further exploration:

  1. What is the significance of the integrating factor in solving linear differential equations?
  2. How would the solution change if C(0)0C(0) \neq 0?
  3. Can you solve this equation for other forms of D(t)D(t), such as D(t)=emtD(t) = e^{-mt}?
  4. Why does C(t)C(t) approach a steady-state value as tt \to \infty when D(t)=D0D(t) = D_0?
  5. How does the parameter kk affect the rate at which the drug leaves the bloodstream?

Tip: Always double-check the units in your differential equations, especially in biological and physical applications, to ensure consistency in your solution.

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Math Problem Analysis

Mathematical Concepts

Differential Equations
First-Order Linear Differential Equations
Integrating Factor
Integration
Exponential Functions

Formulas

dC/dt = -kC + D(t)
C(t) = e^{-kt} ∫_0^t e^{ky} D(y) dy
C(t) = (D_0 (1 - e^{-kt})) / k

Theorems

First-Order Linear Differential Equation Solution Method
Integration by Parts
Constant Coefficient Solutions

Suitable Grade Level

College-Level Calculus (Undergraduate)