The value of the given expression $(-10)^2 + 6 \times -9$ is 46.

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Here are 5 related questions to explore:

1. How do negative numbers affect the order of operations in expressions?
2. What is the difference between $(-10)^2$ and $-10^2$?
3. How do parentheses impact the evaluation of mathematical expressions?
4. How can you simplify expressions that involve both addition and multiplication?
5. What are common mistakes to avoid when working with negative numbers in expressions?

Tip: Always follow the order of operations (PEMDAS: Parentheses, Exponents, Multiplication and Division, Addition and Subtraction) to evaluate expressions correctly.