The expression to evaluate is:

$-1 \times 4 \times (-4)$

Let's break this down step by step:

1. Multiply $-1$ by $4$: $-1 \times 4 = -4$

2. Now, multiply $-4$ by $-4$: $-4 \times (-4) = 16$

So, the final answer is:

$\boxed{16}$

Would you like more details or have any questions?

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Here are five related questions:

1. What is the result of $-2 \times 5 \times (-3)$?
2. How do you evaluate expressions with more than two negative numbers?
3. What is the product of $3 \times (-7) \times (-2)$?
4. How do parentheses affect the order of operations in a multiplication problem?
5. How does multiplying two negative numbers together result in a positive number?

Tip: When multiplying multiple numbers, you can multiply them in any order. Multiplying two negative numbers always results in a positive product.