The smallest 5-digit number is 10,000, and the greatest 5-digit number is 99,999.

To find the difference between these two numbers:

$99,999 - 10,000 = 89,999$

Thus, the difference between the smallest and the greatest 5-digit number is 89,999.

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Related Questions:

1. What is the smallest and largest 4-digit number?
2. How do you find the difference between any two large numbers?
3. What is the significance of 5-digit numbers in mathematics or computing?
4. How do you find the difference between a small and large number in real-world applications?
5. How can the concept of place value help in understanding the range of 5-digit numbers?

Tip: The range of numbers within any number category (like 4-digit or 5-digit) is determined by subtracting the smallest number from the largest one.