To calculate with this matrix, I need to know the specific operation you want to perform. For example, you might want to calculate the determinant, inverse, transpose, or perform matrix multiplication with another matrix. Could you please specify the operation?

If you're interested in the determinant, note that this matrix is a $4 \times 4$ matrix.

Let me know how you'd like to proceed or what operation you'd like to perform!

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Relative Questions:

1. Do you want to find the determinant of this $4 \times 4$ matrix?
2. Are you interested in finding the inverse of this matrix?
3. Would you like to perform matrix multiplication with another matrix?
4. Are you looking to calculate the eigenvalues and eigenvectors of this matrix?
5. Do you want to find the transpose of this matrix?

Tip: When working with larger matrices, understanding the properties of matrices, such as symmetry or singularity, can simplify many calculations.