The expression in the image is:

$\frac{-5}{4^2}$

To simplify:

1. First, calculate $4^2$: $4^2 = 16$

2. Now, divide $-5$ by 16: $\frac{-5}{16}$

So, the simplified result is $-\frac{5}{16}$.

Let me know if you'd like further explanation or details!

Here are some related questions to expand on this:

1. How do you simplify other fractions with exponents in the denominator?
2. What happens if the numerator is also a power of a number?
3. How can you express negative fractions in decimal form?
4. What is the difference between negative exponents and negative numbers in fractions?
5. How would this result change if the denominator was a negative number?

Tip: When simplifying fractions with exponents in the denominator, always calculate the exponent first and then simplify the fraction.