To help determine the next number in this sequence or pattern, I'll first analyze the visible pattern within the numbers. Here are some initial steps:

1. Identify the highlighted numbers: Red-colored numbers or those replaced by "**" symbols might signify particular values or a part of a recurring sequence.
2. Check for arithmetic or geometric progressions: Sometimes, numbers are arranged according to such sequences either horizontally, vertically, or diagonally.
3. Look for modular patterns: Some grids use modular arithmetic, like looking at the last digit or following an increment/decrement pattern.
4. Analyze by rows and columns: Check each row and column for a repeating or predictable sequence, like additions, subtractions, or alternating patterns.

Please confirm if there’s a specific pattern you want analyzed or if you’re aware of any rules guiding the sequence so I can dive deeper.

Do you want a specific approach to identifying the pattern?