The pattern in the numbers can be identified by observing the relationships between the numbers in the columns. Let’s analyze it step by step.

We will break down the values column by column and see if there is a clear relationship (such as addition, subtraction, or multiplication) that helps us find the missing numbers.

Here are the given numbers in a matrix form:

04   45   24   16   89   28
28   25   16   12   20   65
46   85   90   72   72   93
??   69   76   12   ??   ??

Column 1:

We have the numbers: 04, 28, 46, ??.

• The difference between 28 and 4 is $28 - 4 = 24$.
• The difference between 46 and 28 is $46 - 28 = 18$. This gives a decreasing difference (24, then 18). We can assume the next difference is 12, so:
• $46 - 12 = 34$.

Thus, the missing number in the first column is 34.

Column 5:

We have the numbers: 89, 20, 72, ??.

• The difference between 20 and 89 is $20 - 89 = -69$.
• The difference between 72 and 20 is $72 - 20 = 52$. There is no clear arithmetic pattern. However, if we assume the pattern alternates in some way, we could continue using a similar approach, like taking the difference between 72 and 20 (52), but it's more likely this column follows a geometric or less obvious pattern.

But since there's no common pattern, it's difficult to calculate